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Chronic exertional compartments syndrome (CECS) of the lower limb is a condition that is generally under-diagnosed and presents with characteristic symptoms in at risk populations, such as athletes and military recruits.
CECS is characterised by exertional leg pain, which may be variably associated with pain, swelling, loss of function and distal cutaneous numbness related to specific muscle muscle compartments. The most commonly affected compartment is the anterior compartment of the lower leg(51%) followed by the lateral compartment(33%), the deep posterior compartment(13%) and superficial posterior compartment(3%).
Signs and symptoms tend to be localised to the involved muscle compartments. Presenting symptoms include cramping, aching, a feeling of muscles tightness, numbness and tingling, foot drop (often reported as slapping of the foot), and occasionally local swelling or bulging as a result of muscle herniation. These symptoms often occur in a recognisable temporal pattern in a patient, after a consistent time, distance or intensity of exercise. The pain classically becomes worse as exercise progresses, and is usually sufficiently debilitating to require an individual to stop. The symptoms reduce once exercise is stopped and have often resolved within fifteen minutes of cessation. If activity is re-commenced after a brief rest, patients commonly report a reduced length of time prior to onset of further symptoms.

INDICATIONS
The indication for compartment release in Chronic Exertional compartment Syndrome (CECS) is persistent debilitating pain affecting the patient’s activities, confirmed on pressure manometer testing, that has not responded to non-operative management, including physiotherapy, footwear modification, activity reduction and gait retraining.
SYMPTOMS & EXAMINATION
Patients present with symptoms of increased pressure sensation, pain, aching, cramping and occasionally burning in the effected compartment (usually the anterior compartment), that occurs after a consistent period of time of a given provocative exercise. Symptoms resolves with rest however if exercise is re-commenced too quickly, the lag period before onset of symptoms may reduce. There is often numbness and tingling associated with the nerve that passes through the involved compartment, in the case of the anterior compartment this will be the superficial peroneal nerve and might cause numbness over the dorsum of the foot.
Patients’ will complain of increasing weakness of the limb during exercise and this often manifests itself as feeling of the foot slapping when running. This phenomenon is the result of loss of function in the tibialis anterior muscle due to ischaemia, resulting in a temporary foot drop. The symptoms are frequently bilateral. Muscle herniation can also be associated with CECS syndrome which manifests itself as discreet swellings or bulges in the compartment which become worse with exercise.
CECS is not symptomatic when the patient is at rest or performing lower intensity activities, which will help distinguish it from its differential diagnoses.
INTRACOMPARTMENTAL PRESSURE MEASUREMENTS:
The diagnosis of CECS is extremely difficult to establish based on clinical criteria alone; in patients who present with signs and symptoms of chronic exertional compartment syndrome, pre and post exercise intracompartmental pressure measurement is a safe and reliable method of increasing diagnostic accuracy. Whilst there remains some debate regarding pressure thresholds and timing of measurements, most of the described diagnostic criteria are based upon the Pedowitz modified criteria(Am J Sports Med. 1990 Jan-Feb;18(1):35-40). The Pedowitz group proposed that in patients with positive clinical findings, one or more of the following intramuscular pressure criteria were likely to be diagnostic of CECS of the leg
1) a pre-exercise pressure greater than or equal to 15 mm Hg,
2) a 1 minute postexercise pressure of greater than or equal to 30 mm Hg, or
3) a 5 minute postexercise pressure greater than or equal to 20 mm Hg.
IMAGING
Weight-bearing radiographs maybe helpful in excluding degenerative change, stress fractures, deformity, or abnormalities around the syndesmosis, such as osteochondromas or heterotopic ossification. Plain MRI scans rarely show any significant abnormality, although some studies of post-exercise MRI scans suggested that post exercise scans might have an application in future diagnosis as they demonstrate subtle, characteristic abnormalities in the research non-clinical setting. MRI scans are also useful when excluding periosteal reaction or stress fractures, which maybe a differential diagnosis of CECS. Technecium bone scans or spect CT scan maybe helpful in showing more subtle periosteal reactions, which can be seen in medial tibial stress syndrome or shin splints.
ALTERNATIVE OPERATIVE TREATMENT
Fasciotomies of the lower limb are an established method of treatment for CECS, the procedure can be performed in a variety of manners. Traditionally a long incision has been used, more recently a small single incision, 2 incision technique and an arthroscopic technique have been described. My experience is that a long incision is often unnecessary and is associated with an increased risk of wound problems and dehiscence and a slower recovery time when compared to a small single incision, whilst occasionally patients with longer lower limbs will require a 2 incision technique. The arthroscopic technique carries a an increased risk of nerve damage. In those patients with herniation of tibialis anterior through defects in the deep fascia, a fasciotomy is performed in a similar manner to the standard fasciotomy, the fascial defects should not be repaired, as this will not treat the raised intracompartmental pressure which is often associated with the condition.
NON-OPERATIVE MANAGEMENT
A number of studies have looked at gait retraining. Roberts (J R Army Med Corps. 2015 Mar;161(1):42-45) and Sugimoto (J Phys Ther Sci. 2018 Aug;30(8):1056-1062) found different gait patterns in patients with CECS compared to controls which included increased ankle dorsiflexion in swing phase, tendency towards longer step length, longer stance phase and pronounced heel strike in patients with CECS.
Zimmerman (BMJ Open Port Exerc Med. 2019 Mar 19;5(1)) reported a cohort of military patients with CECS who were enrolled on a physical therapy and gait retraining programme emphasising forefoot loading and found 57% improved, and had returned and maintained their usual activities at 2 years.
DIFFERENTIAL DIAGNOSIS
The differential diagnoses for chronic exertional compartment syndrome include medial tibial stress syndrome(shin splints), popliteal artery entrapment syndrome, acquired myopathies and rarely anterior compartment soft tissue tumours.
CONTRAINDICATIONS
Patients with underlying myopathies tend to respond poorly to compartment release, the author’s tend to perform a routine creatine kinase (CK) as a basic screen for myopathy. Active Infection, Peripheral vascular disease and peripheral neuropathy are contraindications..

The patient is positioned supine on the table, as the lower limb generally tends to externally rotate, a sandbag under the affected ipsilateral buttock helps internally rotate the leg and expose the anterior and lateral compartments.
A thigh tourniquet is used to provide a bloodless field and the patient is cleaned with a sterile alcoholic preparation to above the knee.
Instruments: A basic orthopaedic set with scalpel, skin retractors, blunt tipped dissection(McIndoes) scissors, a smiley fasciotomy knife, as well as a sterile ruler.

Patients are encouraged to elevate the leg regularly for 2 weeks. Local anaesthetic is administered for post-operative pain; patient’s are advised to take analgesia regularly for three days, followed by as required.
It is important to manage the swelling post-operatively whilst elevating the leg as much as possible but on a regular basis (5 minutes out of every 30 minutes) Patients are encouraged to exercise, and especially activate their anterior compartment by walking upstairs or walking on their heels. The outer dressings are reduced leaving the small adhesive dress at 72 hours and ice packs or a cryocuff are applied to the calf in order to manage the post-operative swelling. The patient attends dressing clinic at two week to remove the adhesive dressing and then are allowed to bathe, massage the scar and are referred for physiotherapy to work on gait posture, strengthening the anterior compartments. They are allowed to return to general impact activities at 6 weeks and full sports by 10-12 weeks post-operatively.

1. Eur J Orthop Surg Traumatol. 2019 Feb;29(2):479-485. Fasciotomy for chronic exertional compartment syndrome of the leg: clinical outcome in a large retrospective group.
Tam JPH, Gibson AGF, Murray JRD, Hassaballa M.
Tam et al showed that there was a good correlation between pain levels and raised intracompartmental pressure, when they retrospectively reviewed 138 cases over 17 years. The group found that compartment pressure release in CECS significantly reduced pain and increased activity levels in their cohort.
2 Orthop J Sports Med. 2017 Nov 10;5(11). Functional outcomes after surgical management of Isolated Anterolateral Leg Chronic Exertional Compartment Syndrome.
Gatenby G. Haysom S. Twaddle B. Walsh S.
Gatenby et al, in their retrospective study of 36 isolated anterior and lateral compartment releases for CECS in 20 patients, published in the November 2017 Orthopaedic Journal of Sports Medicine, reported excellent outcomes, with improved pain scores, a very low recurrence rate, 90% of patients returned to their pre-morbid level of sport.
3. BMJ Open Sport Exerc Med. 2019 Mar 19;5(1). Conservative treatment of anterior chronic exertional syndrome in the military, with a mid-term follow up.
Zimmermann WO, Hutchinson MR, Van den Berg R, Hoencamp R, Backx FJG, Bakker EWP.
Zimmermann, et al published a retrospective study of a cohort of 75 military patients who were surgically eligible with a diagnosis of CECS or medial tibial stress syndrome, who were treated non-operatively with gait retraining and physical therapy, there was no difference in response between the two groups, at 2 years 57% of patients had maintained a return to active service. They concluded that physical therapy and gait retraining can improve symptoms in a significant population of patients presenting with CECS in a military setting, this may reduce the need for surgical fasciotomy.
4. Arch Orthop Trauma Surg. 2017 Jan;137(1):73-79. Single minimal incision fasciotomy for the treatment of chronic exertional compartment syndrome: outcomes and complications.
Drexler M, Rutenberg TF, Rozen N, Warschawski Y, Rath E, Chechik O, Rachevsky G, Morag G.
11. Am J Sports Med. 1990 Jan-Feb;18(1):35-40. Modified criteria for objective diagnosis of chronic exertional compartment syndrome of the leg.
Pedowitz RA, Hargens AR, Mubarak SJ, Gershuni DH.
Pedowitz et al proposed the criteria for objective diagnosis of chronic exertional compartment syndrome. They proposed that with positive clinical findings, one or more of the following intramuscular pressure criteria were likely to be diagnostic of CECS of the leg
1) a pre-exercise pressure greater than or equal to 15 mm Hg,
2) a 1 minute postexercise pressure of greater than or equal to 30 mm Hg, or
3) a 5 minute postexercise pressure greater than or equal to 20 mm Hg.
12. J Phys Ther Sci. 2018 Aug:30(8):1056-1062. Running mechanics of females with bilateral compartment syndrome.
Sugimoto D, Brilliant AN, d’Hemecourt DA, d’Hemecourt CA, Morse JM, d’Hemecourt PA.
Compared to healthy female runners, bilateral CECS female runners demonstrated different running mechanics including greater overstride and ankle DF angles. The two variables were strongly associated with each other in bilateral CECS female runners, but not in healthy female runners. This may potentially contribute to the mechanism of CECS development.
Tam et al showed that there was a good correlation between pain levels and raised intracompartmental pressure, when they retrospectively reviewed 138 cases over 17 years. The group found that compartment pressure release in CECS significantly reduced pain and increased activity levels in their cohort.
Gatenby et al, in their retrospective study of 36 isolated anterior and lateral compartment releases for CECS in 20 patients, published in the November 2017 Orthopaedic Journal of Sports Medicine, reported excellent outcomes, with improved pain scores, a very low recurrence rate, 90% of patients returned to their pre-morbid level of sport.
3. BMJ Open Sport Exerc Med. 2019 Mar 19;5(1). Conservative treatment of anterior chronic exertional syndrome in the military, with a mid-term follow up.
Zimmermann WO, Hutchinson MR, Van den Berg R, Hoencamp R, Backx FJG, Bakker EWP.
Zimmermann, et al published a retrospective study of a cohort of 75 military patients who were surgically eligible with a diagnosis of CECS or medial tibial stress syndrome, who were treated non-operatively with gait retraining and physical therapy, there was no difference in response between the two groups, at 2 years 57% of patients had maintained a return to active service. They concluded that physical therapy and gait retraining can improve symptoms in a significant population of patients presenting with CECS in a military setting, this may reduce the need for surgical fasciotomy.
4. Arch Orthop Trauma Surg. 2017 Jan;137(1):73-79. Single minimal incision fasciotomy for the treatment of chronic exertional compartment syndrome: outcomes and complications.
Drexler M, Rutenberg TF, Rozen N, Warschawski Y, Rath E, Chechik O, Rachevsky G, Morag G.
11. Am J Sports Med. 1990 Jan-Feb;18(1):35-40. Modified criteria for objective diagnosis of chronic exertional compartment syndrome of the leg.
Pedowitz RA, Hargens AR, Mubarak SJ, Gershuni DH.
Pedowitz et al proposed the criteria for objective diagnosis of chronic exertional compartment syndrome. They proposed that with positive clinical findings, one or more of the following intramuscular pressure criteria were likely to be diagnostic of CECS of the leg
1) a pre-exercise pressure greater than or equal to 15 mm Hg,
2) a 1 minute postexercise pressure of greater than or equal to 30 mm Hg, or
3) a 5 minute postexercise pressure greater than or equal to 20 mm Hg.
12. J Phys Ther Sci. 2018 Aug:30(8):1056-1062. Running mechanics of females with bilateral compartment syndrome.
Sugimoto D, Brilliant AN, d’Hemecourt DA, d’Hemecourt CA, Morse JM, d’Hemecourt PA.
Compared to healthy female runners, bilateral CECS female runners demonstrated different running mechanics including greater overstride and ankle DF angles. The two variables were strongly associated with each other in bilateral CECS female runners, but not in healthy female runners. This may potentially contribute to the mechanism of CECS development.
4. Arch Orthop Trauma Surg. 2017 Jan;137(1):73-79. Single minimal incision fasciotomy for the treatment of chronic exertional compartment syndrome: outcomes and complications.
Drexler M, Rutenberg TF, Rozen N, Warschawski Y, Rath E, Chechik O, Rachevsky G, Morag G.
Drexler et al reported a retrospective series of 95 legs undergoing a single minimal incision fasciotomy for the treatment of CECS, in whom there was a 75% satisfaction rate, they reported 2 wound complications, 8 recurrences and 4 nerve injuries. They concluded single incision fasciotomy provided a long term improvement in function and symptoms.
5. J Orthop Surg Res. 2016 May 24;11(1):61. Single minimal incision fasciotomy for chronic exertional compartment syndrome of the lower leg.
Maffulli N, Loppini M, Spiezia F, D’Addona A, Maffulli GD.
Maffulli et al published a retrospective study of 18 athletes, with CECS who underwent a single, minimal incision fasciotomy. They reported high satisfaction rates, 17 of the 18 athletes returned to the same or higher level of activity than pre injury level, mean return to sporting activity was 8-13 weeks.
6. J Bone Joint Surg Am. 1983 Dec;65(9):1245-51. The surgical treatment of exertional compartment syndrome in athletes.
Rorabeck CH, Bourne RB, Fowler PJ.
Rorabeck et al looked at 12 athletes, retrospectively in the Journal of Bone and Joint Surgery Am. 1983. They found that all patients in the group with purely anterior symptoms achieved complete pain relief following fasciotomy, however, those with associated posterior compartment involvement had a higher recurrence rate following fasciotomy.
7. Eur J Orthop Surg Traumatol. 2014 Oct;24(7):1223-8. Return to activity following fasciotomy for chronic exertional compartment syndrome.
Irion V, Magnussen RA, Miller TL, Kaeding CC.
Irion et al looked at return to play in elite athletes. In those with anterior/lateral compartment release the mean return to sport was 10.6 weeks following fascial release. Those with a four compartment release experienced a longer return to sporting activity. They concluded that fasciotomy was a reliable treatment which allowed elite athletes to return to sports.
8. J R Army Med Corps. 2015 Mar;161(1):42-5. Outcomes of surgery for chronic exertional compartment syndrome in a military population.
Roberts AJ, Krishnasamy P, Quayle JM, Houghton JM.
Roberts et al reported that whilst 49% of patients with CECS experienced an improvement in symptoms post surgical release of the fascia, however they found 36% were no better and 15% were worse off. They highlight that the results of compartment release in a military population were not in line with the results of a civilian or athletic population, however the reasons for this are unclear.
9. Arthroscopy. 2016 Jul;32(7):1478-86. Surgical Management for Chronic Exertional Compartment Syndrome of the Lower Leg: A Systematic Review of the Literature.
Compano D, Robaina JA, Kusnezov N, Dunn JC, Waterman BR.
Compano et al presented a systematic review of the literature on the surgical management for chronic exertional compartment syndrome. They included 24 studies with 1596 patients undergoing open fasciotomy; 54% were military personnel 29% were athletes. The most frequently affected compartment was the anterior compartment (51%) , the lateral compartment(33%), the deep posterior (13%) and the superficial compartment was involved in 3%. 84% were satisfied with the outcome. The study explains that it is difficult to extrapolate these results to the newer small single incision procedures or arthroscopic fasciotomy.
10. J R Army Med Corps. 2018 Sep;164(5):338-342. Effects of anterior compartment fasciotomy on intramuscular compartment pressure in patients with chronic exertional compartment syndrome.
Roscoe D, Roberts AJ, Hulse D, Shaheen AF, Hughes MP, Bennett AN.
Roscoe et al, compared 20 post fasciotomy patients with 20 patients with CECS who had not undergone surgery and 20 asymptomatic patients. THe post operative cohort had intracompartmental pressures lower than the preoperative group and there was no significant difference between their readings and asymptomatic controls.
7. Eur J Orthop Surg Traumatol. 2014 Oct;24(7):1223-8. Return to activity following fasciotomy for chronic exertional compartment syndrome.
Irion V, Magnussen RA, Miller TL, Kaeding CC.
Reference
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