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The operation of the below knee amputation is sadly not an infrequent operation in the foot and ankle surgical world . This is particularly the case in practices which are involved in treatment of the diabetic foot and its complications. It is a devastating consequence of metabolic disease, peripheral vascular insufficiency, tumour infection and trauma . It is a procedure which is ablative and has significant ramifications both in the social arena as also to the patient in terms of his physical and psychological disability that can result from it. The incidence though of major amputations seem to be decreasing in the United Kingdom. Diabetics however are at particular risk and six times more likely to have a lower limb amputation than a non-diabetic. In fact about half of all below knee amputations done in the United kingdom are likely to be due to diabetes. The emergence of sport such as mountain biking motorbike racing as well as other high speed sport also has raised the amputation rates for trauma. There are other fringe groups that may require below knee amputation and among them some controversial indications such as Body Dysmorphism Syndrome, Complex regional pain syndrome, and other chronic painful conditions etc. Patients are often driven to seek this option as result of recalcitrant and unbearable pain often of indeterminate origin.. There is evidence to suggest that such patients have a variable response to surgical ablation of their lower limbs with some suffering severe post operative causalgia and phantom pains whilst others enjoying an excellent result. In these patients it is essential to attempt all other forms of treatment before the patient requests an amputation to ensure that the limb cannot be saved by any other methods currently available.
Extensive preparatory work requires to be done to prepare the patient for this life changing operation. This includes assessment by a rehabilitation specialist, a prosthetist, anaesthetic and pain services, physiotherapy , occupational therapy as well as psychologists and psychiatrists. The use of patient forums to illustrate the positive side of life after amputation has significantly enhanced the recovery from this operation in my practice and has made rehabilitation and the impact of psychological trauma easier to cope with. Counselling including cognitive assessment and learning coping techniques preoperatively are also extremely valuable in increasing the overall patient satisfaction. Recent advances in post operative analgesia including indwelling catheters that administer continuous pain relief has significantly reduced the sever phantom limb pains that often plague the patient long after the procedure.
The most important preoperative consideration in non life threatening amputation is the ability of the patient to have a positive attitude about his operation and to be well informed about the consequences of this procedure. It is indeed often a life saving operation and if done for the right indications, after all non-operative algorithms for the treatment of the patients’ symptoms have been exhausted and all preoperative preparations listed above have been complied with and completed.

INDICATIONS
Infection often associated with diabetes, peripheral vascular disease and gangrene, severe acute trauma with a non viable limb usually involving crush or avulsion injuries of the foot and ankle, blast and war injuries where subsequent die back of tissue is inevitable, acute thrombo-embolic phenomena not amenable to intervention, venous gangrene, paralytic or flail limb, chronic septic complications of trauma such as chronic osteomyelitis, severe rampant infections such as gas gangrene, necrotising fasciitis, and synergitic gangrene, severe deformity with intractable ulceration as in Charcot Arthropathy, crush injuries of the foot and ankle, primary or recurrent tumours such as synovio, chondro and osteosarcoma and malignant melanoma, metastatic and locally invasive tumours such as pigmented villonodular synovitis often in their later stages, failed treatment such as distal bypass for peripheral vascular disease etc
Rarer indications include Complex regional pain syndrome and other pain disorders, Body Dysmoprphism syndrome, venous gangrene chronic granulomatous and infectious conditions such as TB , leprosy and Maduramycosis, severe neuromuscular deformity often with sepsis and ulceration of the foot , sequelae of systemic sepsis as in meningococcal meningitis, severe vasculitis and frostbite, thermal and electrical burns, stroke, polio and its resultant flail deformity etc.
The overall objectives of any below knee amputation remain 1. Removal of source of pain or offending pathology 2. Creation of a healthy stump 2. Prosthetic fitting and regaining ambulation
SYMPTOMS & EXAMINATION
Symptoms are dependant upon the condition and are very varied in their presentation. the principal complaint is often of pain or deformity except in the insensate foot. Examination of the limb for its neurvascular status, septic foci, the extent of skin involvement, amount of skin that is available for cover of the stump, vascularity of the remaining limb, the health of the contralateral limb etc are all important considerations for the procedure. Most importantly a holistic examination of the entire patient including their mental health, social circumstances personal history (particularly smoking), glycaemic state and vital organ function especially in diabetic amputations are all extremely important if a successful outcome is to be expected. Significant time must be spent discussing the operation and its consequences with the patient and carer. The function of the opposite limb is also vital to establish the rehabilitation pathway of the patient postoperatively and is best done in conjunction with a multidisciplinary team involving the prothetist, rehabilitation consultant and his team, physiotherpist, occupational therapist and a psychologist. A thorough understanding of the patients gait and anticipated problems with it should also be assessed. This is particularly the case in non infective non diabetic and non ischaemic patients.In patients with pre-existing scars will be greatly assisted by an examination with a plastic surgeon to help with planning the flap for stump cover. Oncoplastic specialist assistance is mandatory in patients with tumour in order to map out the extent of excision o the limb so as to ensure complete clearance of the tumour.
IMAGING
Dependant on the condition the patient may require plain films, MRI or CT scans, Isotope bone scans, and angiography. Other investigations will depend on the condition for which the amputation is being performed. infectious conditions also require deep tissue samples either pre or per-operatively so as to recognise the organisms responsible for the infection and to plan prophylactic antibiotic cover.
ALTERNATIVE OPERATIVE TREATMENT
These are likely to have been exhausted prior to the decision to amputate and is condition specific
NON-OPERATIVE MANAGEMENT
Again the decision to amputate would have been made after all non operative options have been exhausted
CONTRAINDICATIONS
The main contraindication is the general condition of the patient. The operation itself carries a mortality rate that is dependant upon the condition that created the need for the procedure. Higher mortality rates are seen in diabetics and bilateral amputees as well as patients with poor cardio-respiratory function. A significant amount of blood loss may be poorly tolerated by systemically unwell and cardiac patients . Rampant open sepsis is a contraindication to a routine below knee amputation with primary stump coverage and a guillotine type of amputation may have to be performed with 2nd stage cover of the stump to avoided the dreaded complication of stump wound infection and dehiscence and the need for a higher amputation. The function of the knee is also paramount in effecting a biomechanically efficient below knee amputation. A stiff knee with a flexion contracture greater than 15 degrees is a contraindication for a below knee amputation because of the obvious functional inability to use a prosthesis.

I prefer Spinal or epidural anaesthesia if the patient is suitable to have it: in others general anaesthesia may be preferred. The patient is positioned supine with a sandbag under the ipsilateral buttock so that the tibial tuberosity and crest is facing directly upwards and the limb is not internally or externally rotated. I have tended to use an above knee tourniquet to minimise blood loss. It is let down during the operation intermittently in a non-ischaemic amputation. However I do not use a tourniquet in the ischaemic limb or where there is severe calcific arteriosclerosis for fear of disrupting the vasculature. In infected patients the limb is thoroughly scrubbed preoperatively with antiseptic solution to create as sterile a field as possible. The limb may also be covered after landmarks are identified and exposed only where the actual operation site and the flap are required to be seen. Diathermy is essential for the operation to minimise blood loss. I also use a swab soaked in antiseptic solution to periodically cleanse the operative field particularly in infected limbs.. The essential kit for the procedure are Size 22 , 10 and 15 blades, saws and osteotomes, haemostats, surgical ties both absorbable and nonabsorbable, soft tissue protector, limb bag, wound swabs, bone wax, stump dressing

The post operative period can be turbulent so one must be prepared with the requisite team members including pain specialists and psychiatrist as also with amputation counsellors to encounter problems of phantom pain and the distress some patients will inevitably feel when reality strikes and they now can see the loss of their limb as opposed to merely imagining it. The preoperative preparing of the patient for the postoperative period will be the pivotal aspect of postoperative care and positive reinforcement of the patients condition to him/her is essential.
Protocols vary in different units and depends on the preoperative planning in conjunction with the local prosthetics department. I do not change dressings for 5 days. At 48 hours the drain is carefully removed and this is the reason I do not suture drains in as they can be removed without undoing the dressings. At 5 days the dressing is changed to a simple absorbent adhesive dressing along with crepe bandage over orthopaedic wool and the patient is then allowed to go home. The next review is at two weeks when the sutures are removed and a firm amputation stump sock with compression is applied to further mould the stump. The patient is then referred to the prosthetic department for consideration of prosthetic fitting usually a temporary pneumatic one to begin with if deemed to be suitable although there has been some issues with pressure necrosis etc with this approach. A definitive prosthesis is measured and manufactured to be used when the stump scar thought to have matured which is usually about 6-8 weeks.
Mobilisation of the knee starts from day one both to positively reinforce to the patient that he still enjoys knee function, prevent postoperative knee contracture or stiffness and to decrease the risk of deep vein thrombosis. I also put the patient on prophylactic doses of Daltaparin for this purpose unless there are other contraindications to the same. The stump needs to be watched for signs of secondary bleeding which often occurs after the first week . This is a dangerous sign and often signifies infection or soft tissue necrosis within the stump.

The common causes of morbidity arise from either infection tissue necrosis chronic or phantom pain, unresolved causalgia, mental distress and post traumatic stress reactions as well as chronic depression arising from the perceived failure of treatment resulting in amputation. Most of these can be prevented by the various steps taken preoperatively. Disability after amputation is highly dependant upon the general health of the patient and the presence of co-morbidity such as diabetes and peripheral vascular disease as well as certain personality types. A well motivated healthy young individual with the right processes in place, meticulous preoperative preparation, and working in a unit equipped with a well rehearsed amputation service as well as experienced amputation surgeons will yield excellent results with many patients returning to sports including elite professional sport . This has been further enhanced with intensive rehabilitation postoperatively and the emergence of events such as the ParaOlympics and the Invictus games which are highly successful in showcasing the successes of amputation as a viable modality of treatment.
Factors affecting outcome after traumatic limb amputation
Z. B. Perkins, H. D. De’Ath, G. Sharp and N. R. M. Tai1,
British Journal of Surgery 2012
Pain after amputation
MJE Neil, FRCA FFPMRCA
British Journal of Anaesthesia March 2016
Reference
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