
Learn the Fixation of a diaphyseal femoral fracture with a Depuy-Synthes Expert retrograde/antegrade femoral nail (RAFN) surgical technique with step by step instructions on OrthOracle. Our e-learning platform contains high resolution images and a certified CME of the Fixation of a diaphyseal femoral fracture with a Depuy-Synthes Expert retrograde/antegrade femoral nail (RAFN) surgical procedure.
The retrograde/antegrade femoral nail (RAFN) is a versatile system whose benefits include:
One system of instrumentation for retrograde and antegrade insertion.
One system / implant for left and right femurs.
An anatomic anterior bow that allows easier nail insertion.
All nails are cannulated and can be inserted with either a reamed or unreamed technique.
There is a large range of nail diameters available 9.0 mm to 15.0 mm
There are multiple locking options including; static, dynamic, standard and blade options for osteoporotic bone.
It should be noted that a distal femoral nail is inserted with a retrograde technique and in some literature the words are often used to mean the same thing. However, this shouldn’t be confused with an antegrade nail (e.g. Lateral Femoral Nail – LFN) that is used to treat a distal third femoral fracture.
In a retrospective series by Kim et al., sixty patients undergoing femoral nailing for infra-isthmal fractures were reviewed. Thirty-eight patients were treated with an antegrade nail and twenty-two patients with a retrograde nail. They report no statistical difference in time to union, no difference in malalignment > 10 degrees and no difference in Knee Society scores. They did however find that the IM nail with the shorter working length distal to the fracture showed a strong relationship with nonunion.
In a systematic review and meta-analysis by Koso et al., they report that femoral shaft fractures developed nonunion in 6.6% of unreamed nails and 2.1% of reamed nails (p = 0.002). Therefore if the patient’s physiology will permit reaming of the femoral canal, this lowers the risk of developing a nonunion.
Kim JW et al. Treatment of infra-isthmal femoral fracture with an intramedullary nail: Is retrograde nailing a better option than antegrade nailing? Arch Orthop Trauma Surg 2018;138(9):1241-1247.
Koso RE et al. Healing, nonunion, and re-operation after internal fixation of diaphyseal and distal femoral fractures: a systematic review and meta-analysis. Int Orthop 2018;42(11):2675-2683.
Readers will may also find of use the following OrthOracle techniques:
Open reduction and internal fixation of an open intra-articular distal femoral fracture with Synthes LCP distal femoral plate
Femoral intramedullary nail: Synthes Expert Lateral Femoral Nail (LFN) for impending pathological fracture.
Tibial intramedullary nailing (suprapatella approach): Synthes Expert Tibial Nail.

INDICATIONS
Distal / retrograde femoral nails have a number of indications:
Extra-articular supracondylar distal femoral fractures (they can also be used with caution for intra-articular fractures)
Combined femoral neck and diaphyseal fractures i.e. the neck fracture is treated with an extra-medullary device (e.g. a Dynamic Hip Screw) and the diaphyseal fracture is treated with an intra-medullary device (e.g. femoral nail)
Ipsilateral pelvic and acetabular fractures that need surgery (as the approach for a proximal / antegrade femoral nail may compromise the pelvic / acetabular surgical approach)
Combined ipsilateral femoral and tibial fractures that can both be nailed via the knee (e.g. the floating knee)
Polytrauma patient’s where positioning and fracture reduction on a traction table is contraindicated.
SYMPTOMS & EXAMINATION
Femoral fractures are very painful and in skeletally mature and non-osteopaenic patients are usually caused by high energy mechanisms. The leg may appear clinically deformed or shortened. The patient will be unable to actively move their leg / foot without suffering from severe pain. The leg should not be moved by the examiner however, a full neuro-vascular examination is required.
It should not be forgotten that femoral fractures can bleed a lot and precipitate a shocked patient. In a closed femoral fracture between 1000-1500ml of blood can extravasate into the soft tissues. The thigh may be tense and rarely develop into a compartment syndrome. The pulse, blood pressure, pulse pressure, respiratory rate and mental status need careful assessment and monitoring because with 1500ml of blood loss, the patient may develop class II/III haemorrhagic shock.
IMAGING
Plain x-rays in both an Antero-Posterior (AP) and Lateral (Lat) plane are usually sufficient. However, as the majority of femoral fractures are typically from a high energy mechanism, then more commonly they will have a contrast enhanced trauma CT scan. In most Major Trauma Centres (MTCs), an intravenous radio-opaque contrast is administered during the CT scan and the scan is synchronised with the arterial distribution of the contrast. This is so that any occult bleeding can be identified because the contrast will extravasate out of the vessels and highlight if there is a vascular injury. CT scans also help to rule out any associated injuries such as an ipsilateral femoral neck / pelvic and acetabular fracture.
ALTERNATIVE OPERATIVE TREATMENT
Plating
Femoral fractures can be treated with plates however, it must be remembered that a plate is mechanically weaker than a nail and also requires a greater soft tissue approach to insert. In a cadaveric study comparing the Less Invasive Stabilisation System (LISS) plate against a retrograde femoral nail, the nail demonstrated greater axial stiffness and significantly higher load to failure. The plate had greater torsional stiffness however, under cyclic loading it had greater deformation at the fracture site.
Plates however are generally more suited to intra-articular fractures where the introduction a large diameter drill or nail could cause displacement of the fracture and incongruence of the joint.
External fixation
External fixators have a role in damage control orthopaedics or when there is a femoral deformity that cannot be managed by another method e.g. plate or nail. External fixators on the thigh are particularly difficult for patients to live with and make it very difficult to get dressed, sit on chairs, roll over in bed.
Damage Control Orthopaedics (DCO) vs Early Total Care (ETC). The concept of DCO is to provide rapid emergency surgery that saves life and/or limb while avoiding a negative deterioration in the patient’s physiology. The aim is to maintain a physiological equilibrium and transfer the patient to the intensive care unit for ongoing resuscitation as quickly as possible. Essentially the DCO technique provides temporary fracture stabilisation with minimal physiological disturbance and is done rapidly to prevent any ongoing heat loss which could contribute to the terrible triad of hypothermia / acidosis / coagulopathy. To help with the decision making surrounding these patients Moran et al. proposed a traffic light system based on the patient’s blood lactate level. If the lactate level is < 2 mmol/l (green), then ETC is possible. If it is > 2.5 mmol/l, resuscitation should be continued. If there is an improvement and downward trend in the lactate then ETC may be possible (amber). However, if the lactate remains > 2.5 mmol/l then DCO should be considered (red).
NON-OPERATIVE MANAGEMENT
Femoral fractures can be treated non-operatively with traction only however, the skill required to setup the traction and also nurse the patient for a prolonged period is now diminishing. As part of the initial ‘first aid’ for a femoral fracture, a traction type splint should be applied as soon as possible. The primary benefit of the splint is that it significantly reduces the patient’s pain for transfer from injury scene to hospital. It also reduces the volume of the thigh compartments (anterior, medial, posterior) and helps to tamponade any bleeding at the fracture site and surrounding soft tissues.
CONTRAINDICATIONS
There are a few scenarios where a distal / retrograde femoral nail are contraindicated:
An associated ligamentous knee injury that requires surgical reconstruction e.g. ACL / PCL.
Infection; as this can lead to a septic arthritis of the knee joint (this doesn’t mean that all open fractures cannot be treated with distal / retrograde femoral nails, as with appropriate debridement, then the wound bed is now clean).
Pre-existing femoral deformity.
Moran C, Forward D. The early management of patients with multiple injuries. An evidence-based, practical guide for the orthopaedic surgeon. JBJS Br 2012; 94-B:446-53.
Du Y et al. Comparison of Less Invasive Stabilization System Plate and Retrograde Intramedullary Nail in the Fixation of Supracondylar Fractures in the Elderly: A Biomechanical Study. Orthop Surg 2019;11(2):311-17.

The surgical instrumentation required to perform this procedure are:
Synthes Expert Retrograde/Antegrade Femoral Nail instrumentation (RAFN)
Synthes Reaming System
Synthes F-Tool for fracture reduction (only if needed)
2.5 mm short wires to be used as blocking wires to facilitate fracture reduction
A standard orthopaedic set including scalpel, forceps, scissors, needle holders etc…
A laminar air flow theatre to reduce the risk of developing a deep infection.
Intravenous antibiotics to be given on induction. No post-operative antibiotics. In open fractures; it depends on the quality of debridement and level of contamination. In general, if you are considering antibiotics, then the debridement was probably insufficient (unless soft tissue cover had not been achieved).
No tourniquet as it will prevent access to the proximal nail locking bolt holes.

Routine post-op care would be:
A neuro-vascular assessment of the limb (NB if the patient received a block or regional anaesthesia, they might have abnormal sensation / muscle power).
Bloods to check their haemoglobin and renal function.
Remove the knee bandage in 24-48 hours. Leave the other dressings undisturbed if possible.
Mobilise full weight bearing, with early knee range of motion exercises.
Home when able and to return to clinic in 10-14 days for wound review, trimming / removal of any sutures and a check radiograph to ensure no early failure of the metalwork and to have a comparison view available for future reference.
There is widespread variation in practice amongst Orthopaedic Surgeons for the weight bearing status of patients’ after fracture fixation. Personally I believe that all fractures should be fixed to achieve stability and therefore under normal physiological loads, the fracture / implant construct should be able to withstand day-to-day activity. However, it is important to consider whether the implant is load sharing or load bearing. If the fracture is multi-fragmentary and / or the fracture reduction is not ideal, then the implant would be considered to be load bearing. In these circumstances, then I feel it is appropriate to consider restricting the weight bearing status.
I’m a firm believer in Wolff’s Law that states that the bone in a healthy person will adapt to the loads under which it is placed. I therefore feel that by restricting the weight bearing or loading status of the bone, we inadvertently cause it be weakened as it develops disuse osteopaenia.

Harwood et al. set out to determine the infection rates after damage control orthopaedics (DCO) and primary intramedullary nailing in multiply injured patients with femoral shaft fractures. A total of 192 fractures were included (173 patients). 111 fractures were treated with DCO and then converted to an intramedullary nail. Eighty-one patients were treated with a primary intramedullary nail. Infection was classified as:
Contamination (positive swabs with no clinical change)
Superficial
Deep (requiring surgery)
Removal of hardware (removal of femoral instrumentation or amputation)
They found that contamination was significantly more likely when conversion to an intramedullary nail occurred after more than 14 days (P < 0.05). However, this did not lead to more clinically relevant infections (follow up: mean 19.1 months; median 16.7 months).
Harwood PJ, Giannoudis PV, Probst C, Krettek C, Pape HC. The risk of local infective complications after damage control procedures for femoral shaft fracture. J Orthop Trauma 2006;20(3):181-9.
Some surgeons are concerned about ‘violating’ the knee joint and the risk that a deep infection could lead to a septic arthritis. Also there is concern that it may affect the knee range of motion or precipitate knee pain. In a systematic review by Papadokostakis et al., they found that the incidence of deep infection for retrograde intramedullary nails used to treat distal femoral fractures was 1.4% with a risk of developing a septic arthritis of 0.18%.
The mean knee range of motion was 104 degrees +/- 12.7 degrees and the incidence of knee was pain was 16.5% (50 / 303 patients). Looking at the incidence of knee pain, 24 patients (7.9%) had prominent screws or impingement of the iliotibial band. Nine (2.9%) had prominence of the nail within the joint and five (1.7%) developed post-traumatic osteoarthritis. Fourteen patients (4.6%) however, had pain from an unknown origin.
Papadokostakis G et al. The role and efficacy of retrograde nailing for the treatment of diaphyseal and distal femoral fractures: a systematic review of the literature. Injury 2005;36(7):813-22.
Papers cited previously within the technique:
Kim JW et al. Treatment of infra-isthmal femoral fracture with an intramedullary nail: Is retrograde nailing a better option than antegrade nailing? Arch Orthop Trauma Surg 2018;138(9):1241-1247.
Koso RE et al. Healing, nonunion, and re-operation after internal fixation of diaphyseal and distal femoral fractures: a systematic review and meta-analysis. Int Orthop 2018;42(11):2675-2683.
Moran C, Forward D. The early management of patients with multiple injuries. An evidence-based, practical guide for the orthopaedic surgeon. JBJS Br 2012; 94-B:446-53.
Du Y et al. Comparison of Less Invasive Stabilization System Plate and Retrograde Intramedullary Nail in the Fixation of Supracondylar Fractures in the Elderly: A Biomechanical Study. Orthop Surg 2019;11(2):311-17.
Collinge et al. Is there an optimal proximal locking screw length in retrograde intramedullary femoral nailing? Can we stop measuring for screws? J Orth Trauma 2015;29(10):421-24.
Reference
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