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Fixation of distal third humeral shaft fracture using Synthes LCP extra-articular distal humeral plate

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Using a plate remains the commonest method of internal fixation used for those humeral shaft fractures which require surgical treatment. The location of the fracture determines both the approach and also the type of plate to be used.
For a distal third humeral shaft fracture my preference for using the Synthes extra-articular distal humeral plate stems from the need for adequate fixation. Due to the anatomical shape of the distal humerus this can be difficult to achieve with plates that are not designed for the area. The fracture characteristics and level of the fracture determines the type of plate required but irrespective the principle of having six to eight cortices of hold either side of the fracture is adhered to. For fractures in this region, a standard LCP plate would not normally allow adequate fixation of the distal fragment as it encroaches on the olecranon fossa and can therefore inhibit elbow extension. The design of the Synthes LCP extra-articular distal humeral plate plate however allows fixation distally along the dorsal aspect of the lateral column, leaving the olecranon fossa clear. The plate is also sufficiently robust to allow fixation using a single implant, thus reducing both operating time and extent of exposure.

INDICATIONS:
Fractures involving the humeral shaft are common. They account for 1-3% of adult fractures. The majority of these injuries can be managed conservatively. Indications for surgery can be divided into absolute and relative indications in the acute setting.
Absolute indications include:
Open fractures
Fractures with associated vascular injury requiring surgical repair
Floating elbow fractures involving ipselateral forearm fractures
Fractures complicated by a compartment syndrome
Relative indications include:
Polytrauma patients
Bilateral humeral fractures
Specific fracture characteristics including distraction at fracture site and short oblique or transverse fractures
Patients who elect for surgical fixation to allow earlier mobilisation and therefore potential earlier return to function.
Patients may also require surgery if the fracture fails conservative management, for example due to progressing deformity, pain that is not controllable or a delayed or non-union.

SYMPTOMS & EXAMINATION:
Patients usually present after sustaining a direct blow to the upper arm. These occur in a bimodal distribution either in young patients with high energy trauma and in elderly patients with osteopaenic bone suffering low energy trauma. Spiral fractures of the distal humerus can also be caused by twisting injuries and even arm-wrestling as a cause has been documented in the literature.
Patients present with arm pain, crepitus and deformity. The arm is shortened and usually lies in varus and internally rotated as it rests against the body.
It is important to perform a neurovascular assessment, with particular reference to the radial nerve and brachial artery. The incidence of radial nerve injuries is approximately 16%, although most spontaneously recover.
In high energy injuries, although uncommon, it is important to consider the intercurrent existence of an upper limb compartment syndrome.

IMAGING:
Anteroposterior and lateral radiographs of the humerus should be obtained and should include the joints above and below.
If there is concern regarding proximal extension or distal extension into the elbow joint, a CT scan may be warranted for surgical planning.

CLASSIFICATION:
The OTA/AO Classification is the most useful and commonly used.
Given these fractures are located in the humeral shaft, these are described as “12” with sub-types A (simple), B (wedge) or C (multi-fragmentary).
Type A fractures have been subdivided into spiral fractures (A1), oblique (≥30º) fractures (A2), and transverse (< 30º) fractures (A3).
Type B fractures are divided into intact wedge fractures (B2) and fragmentary wedge fractures (B3).
For types A and B, the location of the fracture is also specified as a-proximal third, b-middle third or c-distal third.
Type C (multifragmentary) fractures are divided into intact segmental fractures (C2) and fragmentary segmental fractures (C3). Type C3 fractures are also subdivided on the basis of location (i-proximal diaphyseal–metaphyseal, j-pure diaphyseal, k-distal diaphyseal–metaphyseal).

ALTERNATIVE OPERATIVE TREATMENT:
Surgical management of humeral shaft fractures include plate fixation, intramedullary nailing and external fixator. Although there are numerous clinical trials and meta-analyses in the literature, there is little evidence and no consensus as to the most suitable treatment, and this is largely dependent on the experience of the surgeon.
Open Reduction and Internal Fixation.
Plate fixation is the commonest method of internal fixation used for humeral shaft fractures when clinically indicated. The location of the fracture determines the approach and the type of plate used. 6-8 cortices of hold either side of the fracture are aimed for.
Broadly speaking, for proximal third humeral shaft fractures, these are commonly fixed with a Synthes Philos plate or other proximal humeral locking plate, utilising a deltopectoral/anterolateral approach. For midshaft fractures, these can be fixed using a large fragment locking compression plate (LCP) utilising an anterolateral or posterior approach. For distal third shaft fractures, the author has a preference for the Synthes LCP extra-articular distal humerus plate, utilising a posterior approach.
Advantages include allowing anatomical reduction of the fracture with interfragmentary compression and the ability to explore the radial nerve if there is a concern regarding its integrity.
Disadvantages include higher blood loss when compared to intramedullary nailing or external fixator due to the greater surgical exposure along with the risk of iatrogenic radial nerve injury. Aesthetically, this also results in a longer scar. For the extra-articular humeral plate, hardware prominence may occur from the distal extension of the plate as it lies on the subcutaneous bony surface of the lateral column and may warrant removal if it remains symptomatic.
Minimally invasive and percutaneous methods are also described.
Intramedullary nail
The results of humeral intramedullary nailing systems are extensively documented in the literature. Published results are comparable to alternative fixation methods. The theoretical advantages include load sharing properties of a nail and smaller scars. Intramedullary nailing may be advantageous particularly if there is clinical concern with regard to the soft tissues, in severely osteoporotic bone and in pathological fractures where there is a concern regarding potential bleeding or if there is a soft tissue component. They also allow splintage of the whole humerus if there are skip lesions. Any decision for surgical management of pathological fractures needs to be taken in conjunction with the local bone tumour unit of course.
Lin et al. suggested there was decreased blood loss with intramedullary nailing compared with plating. However, there is concern with potential damage to the rotator cuff and there is some evidence that nailing using a proximal entry nail is associated with an increased requirement for secondary shoulder surgery.
Harkin et al (2017) showed that there was no difference in union rates or neurologic injury rates when compared to plate fixation.
External Fixator
External fixators are largely used in open fracture management. These are used in initial debridement and temporary stabilisation. It is uncommon for a fracture to be definitively managed by external fixator and the technique carries a high complication rate.

NON-OPERATIVE MANAGEMENT
The majority of humeral fractures can be treated non-operatively with union rates over 90% often reported. Closed humeral shaft fractures are normally managed acutely with a hanging cast or coaptation splint for the first 1-3 weeks before conversion to a functional brace. A coaptation splint extends up to the axilla and over the shoulder and is applied until the swelling improves and the fracture starts to heal. It is applied to counteract the varus and extension forces to the distal fragment. Thereafter, a functional brace is applied to allow mobilisation of the shoulder and elbow.
Criteria for acceptable alignment include <20 degrees anterior angulation, <30 degrees varus angulation and <3cm shortening. Malunion within these parameters rarely results in any functional or cosmetic compromise.
It is worth bearing in mind that there is evidence for increased rates of non-union in fractures manage conservatively. Harkin et al. (2017) reported that non-union rates were 33% if conservatively managed compared to 4% for those surgically fixed. The study also noted that patients with a psychiatric history, including dementia, had a higher non-union rate with conservative management.
CONTRAINDICATIONS
Patients of low functional demand or medically unfit would be relative contra-indications. As part of informed consent, a discussion of outcomes of conservative and operative methods is essential.

The procedure is performed under general anaesthetic and may be supplemented with a nerve block performed by the anaesthetist. It is usually necessary to supplement this with local anaesthetic and adrenaline (1:200000) infiltrated to the operative field to optimise pain relief and to minimise bleeding.
The patient is placed in a lateral decubitus position with the affected arm uppermost. The pelvis is checked to ensure that it is perpendicular to the operating table and the spine is in line and not rotated. The position of the shoulder is checked to ensure it is in an appropriate and comfortable position. The arm is placed in a short ulnar gutter support. Care is taken to ensure that chest wall is well protected from any clamps and metal equipment using gel pads and padding. The elbow can be manipulated during the procedure and can cause pressure areas if not appropriately protected. A surgical pre-scrub prior to routine skin preparation may be performed.
Intermittent calf compression Flotron devices are used during surgery to reduce the risk of thromboembolic disease unless there are any contraindications. Intravenous antibiotics are administered by the anaesthetist. The skin is prepared using Chlorohexidine solution starting at the hand, then onto the whole of the upper limb, up to and including the shoulder. Standard adhesive drapes are used. A tourniquet is not used as it commonly limit proximal exposure of the humerus.

This 20 year old left handed patient sustained the above closed injury when he lost his balance performing squats. He is normally fit and well and there was no neurological deficit at the time of injury.
The radiographs show a spiral fracture of the humeral shaft at the junction of the distal third of the humerus. There is no comminution or intra-articular extension. No further imaging was required for surgical planning.
The distal fragment tends to sit in relative internal rotation and varus due to the weight of the forearm as the arm rests against the body. The pull of the muscles spanning the fracture (biceps, brachialis and triceps) results in shortening of the fracture.

Under general anaesthetic the patient is set up in the lateral decubitus position.
A short ulnar gutter support is applied to support the distal humerus.
Clamps are checked to ensure that the supports are fixed and that there are no pressure areas on the torso.
The mobility of the arm is checked to ensure adequate imaging of the humerus (AP & Lateral views) are with fluoroscopy, particularly with clearance of the table and clamps.

Under antiseptic technique, local anaesthetic with adrenaline 1:200000 is infiltrated along the surgical approach to minimise bleeding.

The whole upper limb is prepped and U drapes are applied up to the level of the axilla to maximise the sterile field.
The hand is covered in a stockinette and wrapped with four inch crepe to isolate the hand. This also keeps the hand clear of any blood.

The radial and ulnar aspect of the upper arm is marked as an aide for orientation during the surgery (A & B)
The landmarks are identified, including the medial and lateral epicondyles. The ulnar nerve is palpated. The outline of the olecranon is palpated and marked.
A longitudinal posterior midline incision is marked, centred over the fracture site. The incision extends distally, curving radially to avoid aligning the incision over a “weight-bearing” surface.

The incision is made using a 15 surgical blade through skin and subcutaneous fat down to the level of the triceps muscle fascia.
Once the appropriate plane at the level of the triceps fascia is identified, fasciocutaneous flaps are raised to allow adequate exposure of the triceps. As depicted, the surgical blade is applied obliquely against the tissues to stay in the correct plane and to not incise into the triceps fascia. If done correctly, the areolar tissue lifts off easily with very little bleeding.
This exposure is developed through the whole length of the incision. Retractors help to expose the field of view. Diathermy to bleeding vessels is applied to achieve haemostasis. Stay sutures using 1 vicryl at the corners of the wound help maintain exposure.

This dissection is continued to the lateral edge of the triceps (A) at the level of the lateral intermuscular septum.
The triceps is mobilised medially off the posterior surface of the humerus. This is usually commenced at the distal humerus. The humerus is palpated and residual fibres of triceps are dissected off the bone using a periosteal elevator.
As the dissection takes you proximally, care needs to be taken to identify the radial nerve as it exits through the lateral intermuscular septum (marked with forceps) from the posterior to the anterior muscle compartments.
The territory of the nerve can be identified easily by the associated vascular bundle.

At this stage, care is taken to dissect using McIndoe scissors under direct vision. The muscle fibres from the medial head of triceps are freed up off the bone.

The bone is better exposed distally using a periosteal elevator.
Once the triceps muscle has been mobilised sufficiently, a Hohmanns retractor can applied over the ulnar aspect of the humerus to aid exposure. Care is taken to ensure that the retractor is against the surface of the bone to ensure there is no injury to the ulnar nerve which lies immediately adjacent.

Cautious dissection is continued proximally as the radial nerve is yet to be identified.
The radial nerve originates from the posterior cord of the brachial plexus and is supplied by nerve roots from C5 – T1. It runs posterior to the axillary artery. In the arm, it runs behind the brachial artery and then passes through the triangular space to reach the spiral groove of back of the humerus. It travels with profunda brachii artery, between the lateral and medial heads of triceps until it reaches the lateral side, where it pierces the lateral intermuscular septum to reach the anterior compartment of the arm. It descends down to cross the lateral epicondyle of the humerus where the nerve terminates by branching itself into superficial and deep branch which continues into the forearm.
The radial nerve gives out motor branches to supply the long head, medial head, and lateral head of triceps. After it emerges out from the spiral groove, it supplies the lateral half of brachialis, brachioradialis and extensor carpi radialis longus.
With regard to sensory branches above the spiral groove, the radial nerve gives off posterior cutaneous nerve of the arm which supplies the skin at the back of the arm. In the spiral groove, it gives off lower lateral cutaneous nerve of the arm and posterior cutaneous nerve of the forearm. The radial nerve also gives articular branches to supply the elbow joint

The fracture site is identified and mobilised. The periosteal elevator aids clearing the bone from muscle fibres and allows delineation of the fracture edges. A reduction clamp allows control of the distal fragment.

The fracture end is delivered and clear of soft tissues that may encroach on the fracture site.

The canal is curetted to freshen up the fracture surface and to clear any debris.

The fracture site is also irrigated with normal saline to remove further debris.

Any fracture haematoma is cleared to allow clear visualisation of the fracture and to assist its anatomical reduction.

Once the haematoma has been cleared, the distal extent of the proximal fragment can be identified (elevated by the periosteal elevator).

Once cleared, the fracture can be reduced and held using the Hey Groves bone clamps. Care is taken to avoid entrapping the ulnar or radial nerves.
Usually, by this stage the radial nerve has been identified and protected.
The ulnar nerve originates from C8-T1 nerve roots and form part of the medial cord of the brachial plexus and descends medial to the brachial artery. At the level of the insertion of coracobrachialis, the ulnar nerve pierces the medial intermuscular septum and enters ther posterior compartment of the arm. It runs distally along the medial edge of triceps and passes medial to the medial epicondyle in the cubital tunnel.
Motor branches include flexor carpi ulnaris and the medial half of flexor digitorum profundus. Sensory branches include the palmar and dorsal branches. These are all given off below the elbow.

Due to the large surface area of the fracture site, the decision was made to reduce the fracture anatomically and stabilise the fracture using 2 lag screws.
This image shows the near cortex being over-drilled using a 3.5mm drill bit (know as the pilot hole). This is drilled using a universal jig
The positioning of the screws can either be placed through the plate or medial or lateral to the plate. Either way, careful planning prior to drilling is required to ensure that the screw does not impinge on plate positioning and that the screw traverses the fracture site as perpendicular to it as possible.
If planning to place a lag screw through the plate, it can be difficult aligning the plate on the bone in a mobile fracture but it is largely determined by the fracture characteristics.

Once drilled, the universal drill guide is inserted into the 3.5mm pilot hole and a smaller 2.5mm drill hole is made in the far cortex.

The far cortex is drilled using the 2.5mm drill. Care is required to only just breach the distal cortex and not overshoot it.

The near cortex is countersunk to allow even distribution of forces generated by the screw head on the bone when it is eventually inserted and the fracture compressed.

A depth gauge is used to determine screw length.

The drill hole needs to be “tapped” in most adult bone.

When the cortical screw is applied, there should be good hold in the far cortex with compression at the fracture site.
Maintenance of reduction is checked to ensure that the lag screw position does not apply a deforming force to the reduction.

Once satisfied, the process is repeated for a second lag screw. This is optional and dependent on fracture pattern, length and stability.

This images show clearly the lag screws in position in a lateral to medial orientation so as not to impinge on plate placement.

Once stabilised, any bone reduction clamps can be removed.
The periosteal elevator is used to raised the soft tissue subperiosteally proximally.
The medial head of triceps lies between the radial nerve and the humerus, thus protecting it from iatrogenic injury as long as the dissection remains subperiosteal.

The appropriate sized Synthes extra-articular distal humeral plate is chosen, allowing 3 to 4 screws to be applied either side of the fracture.
Note, this image depicts a 6 hole plate for demonstration purposes, although an 8 hole plate was used for this operation.
The available sizes of the plate are :
4 hole – 122mm
6 hole – 158mm
8 hole – 194mm
10 hole – 230mm
12 hole – 266mm
14 hole – 302mm
Note that the longer plates may not be available “on the shelf” and may need to be ordered in.

The 2.8mm locking sleeve can be applied to the plate to allow easier manipulation and positioning of the plate on the bone.

The plate is slid proximally in the subperiosteal pocket under the triceps muscle created by the periosteal elevator.

Care is taken to position the plate distally so that the plate or the orientation of the screws does not impinge on the olecranon fossa or the elbow joint.
The distal limb should lie over the dorsal to dorsolateral aspect of the lateral column.
Bending irons may be used to contour the plate to allow it to conform to anatomy. However, in the author’s experience, this is rarely necessary. Once satisfied, it can be temporarily secured using Hey Groves clamps as shown here.

A calibrated 2.8mm drill is applied to the distal locking sleeve. Due to the distal location of the screws, these are usually unicortical and the far cortex (or joint) is not breached.
The measurement is taken against the locking sleeve from the drill bit and the locking screw is applied using a Stardrive screwdriver with torque limiter, once the locking sleeve is removed.

Supplementary locking screws can be applied to secure the position of the plate after ensuring that the plate is centred on the bone proximally.

My experience is that, in variation to the Synthes described operative technique, the plate seems to sit better on the dorsal aspect of the humerus, and the locking screws are therefore orientated postero-anteriorly as opposed to more obliquely.
The most distal screws may only be unicortical to avoid joint penetration, but more proximal screws on the lateral column tend to be bicortical.

Once the plate is stabilised distally, attention is turned to stabilising the plate proximally.
If the fracture and plate are low enough, the whole procedure can be performed through a lateral triceps window, with care taken to identify and protect the radial nerve when retracting triceps muscle medially.
However, with longer plates, the surgeon prefers to locate the radial nerve proximally using the window between the long and lateral head of triceps proximally. The triceps muscle is allowed to sit back in its natural position.

The orientation of the proximal triceps muscle fibres are assessed to identify the interval between the long and lateral head of triceps.
The fascia incised in the midline between the 2 heads.

This plane is developed using McIndoe scissors using a combination of blunt and sharp dissection.
It is best to develop the interval from superficial to deep with care taken to identify the radial nerve when progressing through the layers.
B – Lateral head of triceps
C – Long head of triceps
R – Radial nerve (located at base of approach)

Once the radial nerve has been identified, it can be mobilised medially or laterally to allow safe deployment of the drill and drill sleeve. A vascular sloop is a useful tool for holding the nerve gently retracted.

A carefully placed Hohmann’s retractor is useful to retract the muscle and allow direct visualisation of the nerve and plate.

The same required steps of measuring, tapping and screw application are performed.

A sloop was passed round the radial nerve to facilitate its mobilisation.
This image shows the close proximity of the radial nerve to the plate and screw.
The diameter of the radial nerve can vary in individuals. If it appears smaller that normal, it is worth considering whether the radial nerve has a high take off and may have multiple branches that need to be identified before proceeding with fixation.

Supplementary locking screws can be applied proximally.
Care needs to be taken when applying the locking sleev so as not to damage the radial nerve.

Once fixed, the plate should sit well centred on the humerus.

The image intensifier is covered with sterile drapes and fluoroscopic images are taken. to ensure satisfactory fixation and plate application. One should specifically ensure there is no screw penetration into the joint.

The intra-operative AP fluoroscopic images show that the fracture has been adequately reduced and aligned using 2 interfragmentary lag screws and the plate used as a neutralisation plate.

The distal AP fluoroscopic images show that the contour of the plate allows adequate hold in the distal fragment whilst sparing the olecranon fossa. Clearly there is no possibility of the metalwork impinging on the olecranon fossa and inhibiting terminal extension.

The lateral intra-operative fluoroscopic images show that there is six cortices of hold proximally and is well away from the fracture site.
The reduction is confirmed to be near anatomical and is fixed with 2 lag screws.

The lateral intra-operative fluoroscopic images show that there is adequate fixation of the distal fragment and the screw clearly do not enter the elbow joint.
With respect to this image, the plate can be applied more distally if required. However, this was not necessary for this case.

The wound is irrigated thoroughly with normal saline before closure.
Note that the soft tissues are regularly irrigated throughout the procedure to prevent them from drying out.

Once the retractors are removed, the triceps muscle covers most of the plate and is not usually prominent.

The distal end of the plate is cover by approximating the triceps fascia to the lateral border of triceps using number 1 vicryl.
It is not necessary to approximate it for the whole length of the lateral window approach.

The wound is closed in layers using number 1 vicryl for the triceps fascia.

The fat layer is closed using 2-0 vicryl.

The skin is closed using 3-0 monocryl suture.

The arm is cleaned and dressed.

Half inch steristrips are used to protect the wound and a dressing is applied over the top.
A wool and 6 inch crepe bandage usually provides sufficient post-operative splintage, a backslab not usually being applied unless there is a concern regarding stability of the fixation.

These were the final radiographs 6 months post surgery.
The fracture is radiologically united and there is remodelling at the fracture site.
The patient was asymptomatic with a range of motion from 0-140 in the flexion-extension plane and full pronosupination.

Phase 1 (0-4 weeks):
Sling Immobilisation for comfort.
Wear continuously except for therapy and hygiene/bathing.
Active ROM exercises as tolerated.
Wrist, finger and elbow ROM and shoulder pendulum exercises
No muscle strengthening and avoid aggressive stretching and rotational
stress.
Phase 2 (4-8 weeks):
Discard sling as tolerated
Gradually increases ROM exercises. Stretching should continue to be
slow and to tolerance while avoiding pain.
Restrictions: No strengthening until fracture healing confirmed.
Phase 3 (8-12 weeks)
Shoulder PROM, AAROM and AROM.
Shoulder isometric strengthening with arms at side (IR, ER, scapular
stabilization). At 10 weeks add shoulder resistance strengthening exercises.
Progression should be gradual and in slow increments while avoiding pain.
Phase 4 (12-26 weeks)
Progressive upper-body strengthening may be more aggressive.
Patients ROM, strength and endurance
should be advanced progressively while avoiding pain.
Phase 5 (26+ weeks)
Exercises: Aggressive upper-body strengthening and with initiation of
plyometric training and sports or work specific training. Consider work
conditioning program based on patients job requirements
Restore normal shoulder function and progress to return to sport or
return to work.

Harkin FE, Large RJ. Humeral shaft fractures: union outcomes in a large cohort. J Shoulder Elbow Surg. 2017 Nov;26(11):1881-1888. doi: 10.1016/j.jse.2017.07.001.
Harkin et al. reviewed 126 consecutive humeral shaft fractures and found that there were statistically higher rates of non-union in conservatively managed fractures. In particular, patients with a psychiatric disorder including psychotic disorders, bipolar disorder, multiple involuntary psychiatric admissions, or dementia, was significantly associated with nonunion after conservative management.

Scolaro JA, Voleti P, Makani A, Namdari S, Mirza A, Mehta S. Surgical fixation of extra–articular distal humerus fractures with a posterolateral plate through a triceps-reflecting technique. J Shoulder Elbow Surg. 2014 Feb;23(2):251-7. doi: 10.1016/j.jse.2013.09.020. Epub 2013 Dec 14.
A retrospective study over 5-years including 40 patients with an extra–articular distal humerus fracture treated with a triceps-reflecting approach and an anatomically precontoured posterolateral distal humerus plate followed up over an average of 88 weeks.
95% of patients went on to union. 20% of patients required a secondary procedure. The average QuickDASH score was 17.5. The average visual analog scale scores were 1.9 for pain, 2.3 for function, and 1.6 (range, 0-5) for quality of life. Thirty-five (87.5%) patients reported satisfaction with their outcome.
Trikha V, Agrawal P, Das S, Gaba S1, Kumar A. Functional outcome of extra-articular distal humerus fracture fixation using a single locking plate: A retrospective study. J Orthop Surg (Hong Kong). 2017 Sep-Dec;25(3):2309499017727948. doi: 10.1177/2309499017727948.
95% of patients went on to union. 20% of patients required a secondary procedure. The average QuickDASH score was 17.5. The average visual analog scale scores were 1.9 for pain, 2.3 for function, and 1.6 (range, 0-5) for quality of life. Thirty-five (87.5%) patients reported satisfaction with their outcome.

A retrospective case series of 36 patients with extra-articular distal humerus fractures were managed with extra-articular distal humerus plates with a mean of 15 months follow-up. 34 patients had complete radiological union within 3 months. Complications include one radial nerve palsy (completely resolved), 2 patients developed non-union.


Reference

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